Antitumor and Immunoregulatory Activities of Seleno--Lactoglobulin on S180 Tumor-Bearing Mice

作者：Sun, Su-jun; Feng, Ying-ying; Zhang, Yan^*; Ji, Hai-yu; Yu, Juan; Liu, An-jun^*

来源：Molecules, 2018, 23(1): 46.

DOI：10.3390/molecules23010046

• seleno-beta-lactoglobulin
• S180 tumor-bearing mice
• antitumor
• immunoregulation

Degeneration of immune organs like thymus and spleen has been discovered in tumor-bearing mice; which increases the difficulties on oncotherapy. More effective drugs which target the protection of immune organs are expected to be researched. In this study; we aim to analyze the antitumor and immunoregulatory activities of seleno--lactoglobulin (Se--lg) on S180 tumor-bearing mice. Results indicated that Se--lg exhibited a remarkable inhibitory effect on S180 solid tumors with the inhibition rate of 48.38%; and protected the thymuses and spleens of S180-bearing mice. In addition, Se--lg could also balance the proportions of CD4(+) and CD8(+) T cells in spleens; thymuses and peripheral bloods; and improve Levels of IL-2; IFN-; TNF- in mice serums. -lg showed weaker bioactivities while SeO2 showed stronger toxicity on mice. Therefore our results demonstrated that Se--lg possessed stronger antitumor and immunoregulatory activities with lower side effects and had the potential to be a novel immunopotentiator and antitumor agent.

• 出版日期2018-1
• 单位天津科技大学