A facile regio- and stereoselective synthesis of novel dispirooxindolyl-[acridine-2 %26apos;,3-pyrrolidine/thiapyrrolizidine]-1 %26apos;-ones via 1,3-dipolar cycloaddition of azomethine ylides

作者：Maheswari Shanmugavel Uma; Perumal Subbu^*; Almansour Abdulrahman I

来源：Tetrahedron Letters, 2012, 53(3): 349-353.

DOI：10.1016/j.tetlet.2011.11.048

• Azomethine ylide
• 1,3-Dipolar cycloaddition
• (E)-2-[Arylmethylidene]-3,4-dihydro-1(2H)-acridinones
• Dispirooxindoly[acridine-2 %26apos
• ,3-pyrrolidine]-1 %26apos
• -ones

A facile regio- and stereoselective synthesis of novel dispirooxindolyl-[acridine-2%26apos;,3-pyrrolidine]-1%26apos;-ones and dispirooxindolyl-[acridine-2%26apos;,3-thiapyrrolizidine]-1%26apos;-ones have been accomplished via 1,3-dipolar cycloaddition of azomethine ylides, generated in situ from the reaction of sarcosine/1,3-thiazolane-4-carboxylic acid and substituted isatins, to a series of (E)-2-[arylmethylidene]-3,4-dihydro-1(2H)-acridinones in good yields.

• 出版日期2012-1-18