A Mucormycosis Case in a Cirrhotic Patient Successfully Treated with Posaconazole and Review of Published Literature

作者：Lin Shang Yi; Lu Po Liang; Tsai Kun Bow; Lin Chun Yu; Lin Wei Ru; Chen Tun Chieh^*; Chang Ya Ting; Huang Chung Hao; Chen Chi Yu; Lai Chung Chih; Chen Yen Hsu

来源：Mycopathologia, 2012, 174(5-6): 499-504.

DOI：10.1007/s11046-012-9561-8

• Mucormycosis
• Posaconazole
• Liver cirrhosis

Mucormycosis is an invasive fungal infection associated with a high mortality rate, especially in immunocompromised hosts. Mucormycosis rarely occurs in cirrhotic patients. Here, we report a case of mucormycosis with underlying liver cirrhosis and diabetes mellitus. The patient suffered from maxillary sinusitis and osteomyelitis, and the infection was successfully treated with antifungal agents, surgical debridement, and hyperbaric oxygen therapy. The antifungal treatments used were liposomal amphotericin B, itraconazole, and posaconazole. Although our patient had liver cirrhosis (Child-Pugh classification B), no hepatic decompensation was developed during the treatment course of posaconazole. This is the first report of the safe and effective use of posaconazole for the treatment of mucormycosis in a cirrhotic patient.

• 出版日期2012-12
• 单位河北医科大学