Androgen via p21 Inhibits Tumor Necrosis Factor alpha-induced JNK Activation and Apoptosis

作者：Tang Fangming; Kokontis John; Lin Yuting; Liao Shutsung; Lin Anning^*; Xiang Jialing

来源：Journal of Biological Chemistry, 2009, 284(47): 32353-32358.

DOI：10.1074/jbc.M109.042994

The male hormone androgen is a growth/survival factor for its target tissues or organs. Yet, the underlying mechanism is incompletely understood. Here, we report that androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. Inhibition by androgen requires the transcription activity of androgen receptor (AR) and de novo protein synthesis. Androgen center dot AR induces expression of p21 that in turn inhibits tumor necrosis factor alpha-induced JNK and apoptosis. Furthermore, genetic interruption of p21 alleles abolishes the inhibition by androgen. Our results reveal a novel cross-talk between androgen center dot AR and JNK, thereby providing a molecular mechanism underlying the survival function of androgen.

• 出版日期2009-11-20