Allelotyping analysis at chromosome 13q of high-grade prostatic intraepithelial neoplasia and clinically insignificant and significant prostate cancers

作者：Lu W^*; Takahashi H; Furusato M; Maekawa S; Nakano M; Meng CX; Kikuchi Y; Sudo A; Hano H

来源：Prostate, 2006, 66(4): 405-412.

DOI：10.1002/pros.20363

• loss of heterozygosity
• incidental prostate cancer
• latent prostate cancer
• clinical prostate cancer
• 13q

BACKGROUND. Loss of heterozygosity (LOH) at 13q is one of the most common chromosomal alterations in high-stage prostate cancer, yet little is known about genetic changes in earlier-stage prostate cancer.
METHODS. We used five microsatellite markers at 13q14, 21, and 33 to compare LOH frequencies in 51 lesions of high-grade prostatic intraepithelial neoplasia (HGPIN), 21 cases of incidental prostate cancers (IPCs), 31 cases of latent prostate cancers (LPCs), and 102 cases of clinical prostate cancers (CPCs).
RESULTS. The frequency of LOH at 13q with at least 1 marker was 0%, 38%, 56%, and 49% in HGPIN, IPCs, LPCs, and CPCs, respectively. No statistically significant difference was found between the types of prostate cancer. Allelic loss at 13q14 was significantly more frequent in pT4 tumors than in earlier-stage tumors (P = 0.011).
CONCLUSIONS. Allelic loss at 13q is not only an important event in the metastasis of prostate cancer, but also associated with the initiation of the turner.

• 出版日期2006-3-1