Discrimination between Two Endocannabinoids

作者:Ueda Natsuo*; Tsuboi Kazuhito
来源:Chemistry & Biology, 2012, 19(5): 545-547.
DOI:10.1016/j.chembiol.2012.05.001

摘要

Monoacylglycerol lipase (MAGL) deactivates 2-arachidonoylglycerol (2-AG), an endogenous ligand of cannabinoid receptors (endocannabinoid). In this issue of Chemistry & Biology, Chang and colleagues report an extremely specific MAGL inhibitor that should be useful to distinguish between actions of 2-AG and anandamide, another endocannabinoid.

  • 出版日期2012-5-25