Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis

作者：Du Sienmi; Sandoval Francisco; Trinh Pauline; Voskuhl Rhonda R^*

来源：Journal of Neuroimmunology, 2010, 219(1-2): 64-74.

DOI：10.1016/j.jneuroim.2009.11.018

• Multiple sclerosis
• Experimental autoimmune encephalomyelitis
• Estrogen
• Interferon-beta
• Cytokine

We studied the effects of combination treatment with an anti-inflammatory agent, interferon (IFN)-beta, and a putative neuroprotective agent, an estrogen receptor (ER)-beta ligand, during EAE Combination treatment significantly attenuated EAE disease severity, preserved axonal densities in spinal cord, and reduced CNS inflammation. Combining ER beta treatment with IFN beta reduced IL-17, while it abrogated IFN beta-mediated increases in Th1 and Th2 cytokines from splenocytes Additionally, combination treatment reduced VLA-4 expression on CD4(+) T cells, while it abrogated IFN beta-mediated decreases in MMP-9.

• 出版日期2010-2-26