Microwave-Assisted Method for Simultaneous Hydrolysis and Extraction for Preparation of Geniposidic Acid fromEucommia ulmoidesBark Using Basic Imidazolide Ionic Liquid

作者：Lili, Li; Yupin, Guo; Chunchao, Zhao; Mengxia, Wei; Junling, Liu; Yuangang, Zu; Fei, Wang; Lei, Yang

来源：International Journal of Chemical Engineering, 2016, 2016: 1-11.

DOI：10.1155/2016/2135350

<jats:p>In order to hydrolyze geniposide and extract geniposidic acid, a novel microwave irradiation heating method for simultaneous hydrolysis and extraction for preparation of geniposidic acid from<jats:italic>Eucommia ulmoides</jats:italic>bark using basic imidazolide ionic liquid was developed in this work. Basic ionic liquid paired by imidazolide anion and 1-hexyl-3-methylimidazolium cation ([C6mim]Im) was used as a dual hydrolysis catalyst and extraction solvent in the proposed approach. The optimal concentration of [C6mim]Im was 0.4 mol/L. And the independent parameters optimized by Box-Behnken design (BBD) based on single-factor tests were as follows: microwave irradiation time of 20 min at power of 415 W and liquid-solid ratio of 15 mL/g. Yield of geniposidic acid was increased to<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">3.41</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">0.17</mml:mn></mml:math> <jats:italic>μ</jats:italic>mol/g. DM130 macroporous resin, after reaction, was selected to separate geniposidic acid from hydrolysate. The plant materials with different treatment were analyzed by scanning electron microscopy (SEM) and thermogravimetric analysis (TG). The analysis of SEM and TG further indicated that IMSHE is an efficient preparation method for geniposidic acid. It is reasonable to assume that the method and the dual hydrolysis catalyst and extraction solvent would offer an alternative for the preparation of some other kinds of bioactive substances from plant materials.</jats:p>

• 出版日期2016
• 单位东北林业大学