The clinical and diagnostic role of microRNAs in ovarian carcinoma

作者：Davidson Ben^*; Trope Claes G; Reich Reuven

来源：Gynecologic Oncology, 2014, 133(3): 640-646.

DOI：10.1016/j.ygyno.2014.03.575

• MicroRNA
• Ovarian carcinoma
• Diagnosis
• Chemotherapy
• Prognosis

Objective. MicroRNAs (miRNAs, miRs) are non-coding RNAs which post-transcriptionally regulate miNA synthesis. Data regarding the expression and clinical relevance of miRNAs and the miRNA-regulating machinery in ovarian carcinoma has been rapidly expanding in recent years. This review presents current knowledge in this area.
Methods. PubMed search was undertaken using the terms 'ovarian' and 'microRNA'.
Results. A total of 492 papers were identified, of which approximately 100 were publications in English focusing exclusively or partly on clinical ovarian carcinoma specimens. These studies have identified multiple miRNAs with a potential role in the diagnosis, biology and progression of ovarian carcinoma, as well as on predicting chemoresponse and determining prognosis.
Conclusions. The presented data support a clinical role for miRNAs in ovarian carcinoma and suggest that miRNA-regulated pathways may be of relevance for novel therapeutics. Novel technologies offer new possibilities for wide-scale miRNA-based classification of OC. Further genomic research focusing on larger series of tumors of similar histological type in combination with experimental approaches is likely to expand our understanding of the role of miRNAs in this cancer.

• 出版日期2014-6