AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

作者：Welcker Daniela; Jain Manaswita; Khurshid Safiya; Jokic Mladen; Hoehne Martin; Schmitt Anna; Frommolt Peter; Niessen Carien M; Spiro Judith; Persigehl Thorsten; Wittersheim Maike; Buettner Reinhard; Fanciulli Maurizio; Schermer Bernhard; Reinhardt Hans Christian^*; Benzing Thomas^*; Hoepker Katja

来源：Oncogene, 2018, 37(11): 1503-1518.

DOI：10.1038/s41388-017-0054-6

A fundamental principle in malignant tranformation is the ability of cancer cells to escape the naturally occurring cellintrinsic responses to DNA damage. Tumors progress despite the accumulation of DNA lesions. However, the underlying mechanisms of this tolerance to genotoxic stress are still poorly characterized. Here, we show that replication stress occurs in Kras-driven murine lung adenocarcinomas, as well as in proliferating murine embryonic and adult tissues. We identify the transcriptional regulator AATF/CHE-1 as a key molecule to sustain proliferative tissues and tumor progression in parts by inhibiting p53-driven apoptosis in vivo. In an autochthonous Kras-driven lung adenocarcinoma model, deletion of Aatf delayed lung cancer formation predominantly in a p53-dependent manner. Moreover, targeting Aatf in existing tumors through a dual recombinase strategy caused a halt in tumor progression. Taken together, these data suggest that AATF may serve as a drug target to treat KRAS-driven malignancies.

• 出版日期2018-3