Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst

作者：Friis Stig D; Skrydstrup Troels^*; Buchwald Stephen L

来源：Organic Letters, 2014, 16(16): 4296-4299.

DOI：10.1021/ol502014b

A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading and only a slight excess of CO. Some products are unattainable by traditional carbonylative coupling.

• 出版日期2014-8-15