Cerebrospinal fluid penetration of tigecycline

作者：Pallotto Carlo^*; Fiorio Maurizio; D'Avolio Antonio; Sgrelli Alessio; Baldelli Franco; Di Perri Giovanni; De Socio Giuseppe Vittorio

来源：Scandinavian Journal of Infectious Diseases, 2014, 46(1): 69-72.

DOI：10.3109/00365548.2013.837957

• Tigecycline
• CSF
• pharmacokinetics

We report, in a clinical setting, the tigecycline concentration and area under the concentration-time curve (AUC) - both in blood and in cerebrospinal fluid (CSF) - of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC(0-12) ratio was 0.067.

• 出版日期2014-1