A comparison of uric acid levels in Black African vs Caucasian women from South Africa: the POWIRS study

作者：Palmer I M^*; Schutte A E; Huisman H W; Van Rooyen J M; Schutte R; Malan L; Malan N T

来源：Ethnicity & Disease, 2007, 17(4): 676-681.

• uric acid
• African
• caucasian
• cardiovascular function
• metabolic syndrome

Objectives: Elevated levels of uric acid are often associated with cardiometabolic risk factors. The aim of this study was to determine whether uric acid levels differ between African and Caucasian women and whether uric acid is associated with cardiometabolic risk factors within the two ethnic groups.
Methods: Women from African (N=102) and Caucasian (N=115) descent were recruited and their uric acid levels measured. Anthropometric measurements included height (stature), weight, and waist circumference. Correlations between uric acid and cardiometabolic variables within each ethnic group were also determined.
Results: African women had significantly lower levels of uric acid (P<.01) and significantly higher levels of blood pressure (P=.05) compared to the Caucasian women. There was a significant increase in blood pressure from the lower to higher uric acid tertiles in the African women. Uric acid strongly correlated with waist circumference in both ethnic groups.
Conclusions: Despite their higher blood pressure, the African women had lower uric acid levels, vet they showed a significant increase in blood pressure from a low uric acid tertile to high uric acid tertile, which was not noticeable in the Caucasian women. A possible explanation is a lower waist circumference in African women compared to Caucasian women.

• 出版日期2007
• 单位西北大学