Dual Anti-angiogenic Chemotherapy with Temozolomide and Celecoxib in Selected Patients with Malignant Glioma Not Eligible for Standard Treatment

作者：Kerschbaumer Johannes; Schmidt Franziska Anna; Grams Astrid Ellen; Nowosielski Martha; Pinggera Daniel; Brawanski Konstantin Robert; Petr Ondra; Thome Claudius; Tuettenberg Jochen; Seiz Marcel; Freyschlag Christian Franz^*

来源：Anticancer Research, 2015, 35(9): 4955-4960.

• Glioblastoma
• dual anti-angiogenic chemotherapy
• temozolomide
• celecoxib

Aim: Due to their high rate of neo-angiogenesis, malignant gliomas may qualify for treatment with anti-angiogenic substances. We report on a series of patients with malignant glioma not eligible for standard postoperative combined radiochemotherapy due to decreased health status. Patients and Methods: A total of nine patients with malignant glioma, postoperatively presenting with a Karnofsky performance score (KPS) below 70, were treated with standalone metronomic low-dose chemotherapy with temozolomide and celecoxib (cyclo-oxygenase-2 inhibitor). Overall survival was defined as the primary end-point and the functional status (KPS) and time to progression as secondary end-points of our analysis. Results: The median KPS after surgery was 60. Treatment achieved a decrease in tumor and edema volume and, more importantly, preserved the functional status defined as the ability to care for self (KPS 70%) until disease progression. No notable side-effects were recorded. Conclusion: In patients with decreased general condition (KPS <70), not eligible for standard treatment, antiangiogenic therapy offers a reasonable alternative approach. Our results indicate prolonged survival and preserved quality of life in comparison to best supportive care.

• 出版日期2015-9