A new fluorescent probe for colorimetric and ratiometric detection of sulfur dioxide derivatives in liver cancer cells

作者：Li, Dong-Peng; Wang, Zhao-Yang; Cui, Jie; Wang, Xin; Miao, Jun-Ying; Zhao, Bao-Xiang^*

来源：Scientific Reports, 2017, 7(1): 45294.

DOI：10.1038/srep45294

• TURN-ON PROBE
• LIVING CELLS
• SELECTIVE DETECTION
• SO2 DERIVATIVES
• SULFITE
• BISULFITE
• MITOCHONDRIA
• SENSOR
• CYSTEINE
• HYBRID

A new ratiometric fluorescent probe was constructed with hemicyanine and 7-nitrobenzofurazan for detection of sulfur dioxide derivatives (HSO3-/ SO32-). The ratiometric response mode could be attributed to the efficient FRET (Forster resonance energy transfer) platform. The probe exbihited some desirable properties including fast response (within 2 minutes), good selectivity and high sensitivity. Moreover, the probe could detect endogenous HSO3- in liver cancer cells rather than normal liver cells, implying the diagnosal potential of the probe.

• 出版日期2017-3-28
• 单位山东大学