Mechanisms of Tumor and Viral Immune Escape from Natural Killer Cell-Mediated Surveillance

作者：Groth Ariane; Kloess Stephan; von Strandmann Elke Pogge; Koehl Ulrike; Koch Joachim^*

来源：Journal of Innate Immunity, 2011, 3(4): 344-354.

DOI：10.1159/000327014

• Natural killer cells
• Innnnunosurveillance
• Tumor immune escape
• Viral immune evasion
• Natural killer cell therapy
• Ligand shedding
• NKG2D
• Neuroblastoma

Human natural killer (NK) cells recognize and efficiently eliminate MHC class I low or negative malignant targets and virally infected host cells, without requirement for prior sensitization. However, viruses and various tumor cells display elaborate adaptations to evade and overcome immunosurveillance. The current review focuses on escape mechanisms of viruses and malignantly transformed 'stressed' cells to evade from NK cell cytotoxicity. A general overview of recent clinical studies using allogeneic donor NK cells is given, summarizing first data about a possible benefit for patients suffering from high-risk leukemia and solid tumors. Finally, the review discusses the future perspectives and hypotheses aiming to improve therapeutic NK cell strategies against tumor immune escape mechanisms.

• 出版日期2011