科研之友
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摘要
The heterocoupling between 2-nitrobenzoic and 2,6-dimethoxybenzoic acids was studied. It was demonstrated that the [PdCl2/Cu(OH)(2):0.2/0.75 equiv.] catalytic system can catalyze this reaction with significant yield. Further optimizations (i.e.: sources and loadings of copper and palladium salts, base) allowed to isolate the biaryl in 70 % yield. A catalytic cycle that accounts for the observed results is proposed. While the bi-metal catalyst has shown high yields with some substrates, it is only able to catalyze the decarboxylative coupling in high yield for some of the substrates studied.
- 出版日期2014-11
