New triterpene glycoside and other chemical constituents from the leaves of Swartzia apetala Raddi var. glabra

作者：de Araujo Marcelo F^*; Curcino Vieira Ivo J; Sant'Anna Carlos M R; da Silva Daniel Rosa; Vitorino Maia Ana Isabel; Braz Filho Raimundo; Vieira da Motta Olney; Mathias Leda

来源：Natural Product Research, 2013, 27(20): 1888-1895.

DOI：10.1080/14786419.2013.782493

• Swartzia apetala
• triterpene saponin
• antifungal activity

A new triterpene saponin (1) was isolated from a methanol extract of Swartzia apetala Raddi var. glabra, together with the flavonoids mauritianin (2), kaempferol (3) and the triterpene saponin -D-glucopyranosyl 3-hydroxy-olean-12-en-28-oate (4). These compounds were characterised on the basis of their spectral data, mainly one-dimension (1D; H-1, C-13, APT) and two-dimension (2D; H-1-H-1-COSY, HMQC and HMBC) nuclear magnetic resonance (NMR) and HR-ESI-MS, and comparison with values in the literature. The analysis by HR-ESI-MS showed a mass compatible with that of triterpene saponin 1. This proposal was supported by molecular modelling. LC-HR-ESI-MS experiment was also used to evaluate the purity of 1 and allowed to speculate about the possibility of the presence of 5 in very small quantity. The extract and four compounds were assayed for antifungal activity against nine strains of Candida spp.

• 出版日期2013-10-1