Comparison of Core Needle Biopsy and Excision Specimens for the Accurate Evaluation of Breast Cancer Molecular Markers: a Report of 1003 Cases

作者：Chen, Jie; Wang, Zu; Lv, Qing^*; Du, Zhenggui; Tan, Qiuwen; Zhang, Di; Xiong, Bingjun; Zeng, Helin; Gou, Juxiang

来源：Pathology and Oncology Research, 2017, 23(4): 769-775.

DOI：10.1007/s12253-017-0187-5

• Breast cancer
• Core needle biopsy
• Hormone receptor
• HER2
• Ki-67
• Molecular markers

In this study, we compared the accuracy of marker evaluation in core needle biopsy (CNB) specimens versus excision specimens (ESs) from breast cancer patients. This retrospective study used data collected from the breast cancer database at the West China Hospital, China. Immunohistochemistry (IHC) results from CNB specimens and ESs were compared, using estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 as markers. Molecular subtyping and endocrine therapy usage correlations based on CNB samples and ESs were evaluated. The results obtained from CNB samples and ESs exhibited substantial agreement for the detection of ER (kappa = 0.522), PR (kappa = 0.441), and HER2 (kappa = 0.451), and also influenced endocrine therapy usage. Fair and poor correlations were observed for Ki-67 staining and molecular subtyping (kappa = 0.195), respectively. This disagreement might be attributable to a combination of heterogeneity and large tumor size. This study indicates that the discordance rate in molecular marker staining between CNB specimens and ESs is significant enough that results obtained with CNB specimens should be used cautiously or verified using ESs.

• 出版日期2017-10
• 单位四川大学