AN in vitro ANTIBACTERIAL AND ANTICANDIDAL ACTIVITY OF Sonneratia alba (J. SMITH)

作者：Manilal Aseer^*; Merdekios Behailu; Gezmu Tigist; Idhayadhulla Akbar

来源：Thalassas: An International Journal of Marine Sciences , 2015, 31(2): 67-73.

• Mangrove extract
• Sonneratia alba
• antimicrobial compounds
• chemical constituents
• phyto-pharmaceutical drugs

The aim of the present study was to assess the in-vitro anti-microbial efficacy of Sonneratia alba against the cluster of human and shrimp pathogenic microorganisms and to delineate its bioactive principles through Gas Chromatographic-Mass Spectroscopic (GC-MS) analysis. In this research, an organic extract of S. alba was thoroughly examined for in-vitro anti-microbial activity against five species of clinical isolates, nine human-type culture pathogens and five type cultures (microbial-type culture collection) of prominent shrimp pathogens and six pathogenic Vibrio strains appropriated from the moribund tiger shrimp (Penaeus monodon). The S. alba extracted with medium polar organic solvent, ethyl acetate has yielded crude extract that efficiently obliterate the growth of all tested pathogens. Of the pathogens screened, shrimp pathogens were the most sensitive organisms while clinical pathogens proved to be bit resistant. The gas chromatography along with mass spectrometry of the crude extract has construed the active compound to be 'Squalene,' (48.6 %) which is instrumental in decimating the bacterial growth. The overall activity profile arrived at a conclusion clearly deducing that S. alba with its inhibitory traits could be renewable biological resource which can be exploited for the production of novel natural human and veterinary-grade phyto-pharmaceutical drugs in future to counter re-emerging contagious maladies.

• 出版日期2015-7