A facile synthetic route for 2-pyridyl derivatives: direct preparation of a stable 2-pyridylzinc bromide and its copper-free and pd-catalyzed coupling reactions

作者：Kim Seung Hoi; Rieke Reuben D^*

来源：Tetrahedron Letters, 2009, 50(38): 5329-5331.

DOI：10.1016/j.tetlet.2009.07.004

Direct preparation of 2-pyridylzinc bromide has been developed. interestingly, the subsequent Coupling reactions with acid chlorides have been carried out without any transition metal catalyst. 2-Pyridylaryl compounds, symmetrical and Unsymmetrical 2,2'-bipyridines were also Successfully obtained from palladium-catalyzed coupling reactions of 2-pyridylzinc bromide under mild conditions.

• 出版日期2009-9-23