Mining the B Cell Repertoire for Broadly Neutralizing Monoclonal Antibodies to HIV-1

作者：Kwong Peter D; Mascola John R; Nabel Gary J^*

来源：Cell Host & Microbe, 2009, 6(4): 292-294.

DOI：10.1016/j.chom.2009.09.008

Monoclonal antibodies that effectively neutralize HIV-1 have been widely sought, yet few have been isolated. Now, technological advances in sera evaluation, B cell stimulation, microneutralization, and antibody cloning have allowed Burton and colleagues to identify two broadly neutralizing monoclonal antibodies, PG9 and PG16, which provide insights for HIV vaccine design.

• 出版日期2009-10-22