A painful TR(i)P to lysosomes

作者:Gu Mingxue; Xu Haoxing
来源:The Journal of Cell Biology, 2016, 215(3): 309-312.
DOI:10.1083/jcb.201610067

摘要

The ion channel TRPA1 detects noxious stimuli at the plasma membrane of neurons and elicits pain and inflammation. In this issue, Shang et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603081) report that TRPA1 also localizes to lysosomal membranes of neurons, releasing intracellular Ca2+ to trigger vesicle exocytosis and neuropeptide release.

  • 出版日期2016-11-7