Hydrodefluorinations by low-valent niobium catalyst

作者：Fuchibe Kohei; Ohshima Yoshitaka; Mitomi Ken; Akiyama Takahiko^*

来源：Journal of Fluorine Chemistry, 2007, 128(10): 1158-1167.

DOI：10.1016/j.jfluchem.2007.06.003

• C-F bond activation
• catalysis
• fluorobenzene
• hydrodefluorination
• niobium
• reduction
• trifluoromethylpyridine
• trifluorotoluene

Catalytic hydrodefluorinations of organofluorine compounds by low-valent niobium catalyst were developed. In the presence of niobium(V) chloride (typically, 5 mol%), fluorobenzenes, (alpha,alpha,alpha-trifluorotoluenes and (trifluoromethyl)pyridines were hydrodefluorinated with lithium aluminum hydride to give the corresponding benzenes, toluenes and methylpyridines in good yields, respectively.

• 出版日期2007-10