科研之友
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摘要
Aims: To investigate the relationship between oxidative stress and serum levels of pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis. @@@ Methods: Seventy-three patients presenting to hospital with diabetic ketoacidosis or non-ketotic hyperglycemia were studied. Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), 8-iso-prostaglandin F2 alpha (8-iso-prostaglandinF2 alpha, 8-iso-PGF2 alpha), tumor necrosis factor receptor-I (TNF-RI), interleukin -1 beta (IL-beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were measured in all patients. The patients were then given an intravenous infusion of insulin 0.1U.kg-1.h-1, as well as fluids, symptomatic therapy and parenteral and intravenous nutrition. @@@ Results: @@@ 1. Before treatment, SOD and TAC were significantly lower (P < 0.05), whereas MDA and 8-iso-PGF2 alpha were significantly higher (P < 0.05) in patients with hyperglycemic crises compared to controls. After treatment, SOD and TAC significantly increased (P < 0.05), while MDA and 8-iso-PGF2 alpha significantly decreased (P <0.05). @@@ 2. TNF-RI, IL-1 beta TNF-alpha and IL-6 were significantly higher, both before and after treatment, in patients with hyperglycemic crises compared to controls (P < 0.05). @@@ 3. Before treatment, IL-6 and TNF-alpha were positively correlated with 8-iso-PGF2 alpha (r = 0.32, r = 0.36, P < 0.05) in patients with hyperglycemic crises. After treatment, IL-6 and SOD were negatively correlated within patients (r = -0.33, P < 0.05). Multiple regression analysis indicated that 8-iso-PGF2 alpha affects the level of serum IL-6. @@@ Conclusion: Patients with hyperglycemic crises have significantly increased oxidative stress and dysregulated serum pro-inflammatory cytokines that can be effectively treated by intensive insulin therapy.
- 出版日期2014-9
- 单位厦门大学
