A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity

作者：Segalen Isabelle; Fali Tinhinane; Pers Jacques Olivier; Le Meur Yann; Youinou Pierre^*; Loisel Severine

来源：Autoimmunity Reviews, 2011, 10(4): 218-221.

DOI：10.1016/j.autrev.2010.10.005

• B lymphocyte
• Graft-versus-host disease
• Regulatory B cell
• Antibody
• Autoimmunity
• Rituximab
• Stem cell transplantation
• BAFF (BLyS)

Following allogenic hematopoietic stem cell transplantation (HSCT), patients with autoimmune disease or hematopoietic malignancy may develop acute or chronic graft-versus-host (GvH) disease. B lymphocytes, from the recipient as well as from the donor, have recently been implicated in the pathogenesis of such disturbances. Their deleterious effects are accounted for by other tasks B lymphocytes accomplish than the antibody production. We highlight herein some recent observations in the context of B cells in the GvH disease.

• 出版日期2011-2