ALPHA HELIX PREDICTION BASED ON METROPOLIS-HASTINGS SAMPLING

作者:Ma Lingyu*; Reisert Marco; Wirth Christophe; Hunte Carola; Ronneberger Olaf; Burkhardt Hans
来源:8th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro, 2011-03-30 to 2011-04-02.

摘要

Accurate identification of protein secondary structures is beneficial to the structural interpretation of low-resolution X-ray and EM electron density maps. Existing alpha helix identification methods mainly focus on locally voxelwise classification and then link the helix-voxels based on post-processing processes. In this paper, a novel alpha helix identification approach, named as SSEPredictor, based on Metropolis-Hastings sampling is proposed, which can provide both locally and globally optimized prediction for alpha helical structures in low-resolution electron density maps. The approach has been tested on X-ray crystallographic electron density maps at 8 angstrom resolution. The experimental results show that the identification accuracy is promising.

  • 出版日期2011