Association of Human Development Index with rates and outcomes of hematopoietic stem cell transplantation for patients with acute leukemia

作者：Giebel Sebastian^*; Labopin Myriam; Ehninger Gerhard; Beelen Dietrich; Blaise Didier; Ganser Arnold; Bacigalupo Andrea; Czerw Tomasz; Holowiecki Jerzy; Fagundes Evandro M; Nowara Elzbieta; Frassoni Francesco; Rocha Vanderson

来源：Blood, 2010, 116(1): 122-128.

DOI：10.1182/blood-2010-01-266478

Human Development Index (HDI) is used by the United Nations Organization to measure socioeconomic achievements of countries. We evaluated the association of HDI with rates and outcomes of hematopoietic stem cell transplantation (HSCT) for patients with acute leukemia. For the analysis of HSCT rates, all adults with acute leukemia (n = 16 403) treated in 30 European countries, between 2001 and 2005, were included. Association of HDI with the outcome was analyzed for 2015 patients with acute myeloid leukemia treated with myeloablative allotransplantation. Countries were classified according to HDI quintiles. Highly significant correlation was found for HDI and the total number of HSCT per population (R = 0.78; P < .001), as well as separately for sibling HSCT (R = 0.84; P < .001), unrelated HSCT (R = 0.66; P < .001), and autologous HSCT (R = 0.43; P = .02). The probabilities of leukemia-free survival for 5 consecutive groups of countries with increasing HDI were: 56%, 59%, 63%, 58%, and 68% (P = .01). In a multivariate analysis, transplantations performed in countries belonging to the upper HDI category were associated with higher leukemia-free survival compared with the remaining ones (HR = 1.36, P = .008), which resulted mainly from reduced risk of relapse (HR = 0.72, P = .04). We conclude that, in Europe, the HDI is associated with both rates and results of HSCT for acute leukemia. (Blood. 2010; 116(1): 122-128)

• 出版日期2010-7-8