Direct Use of Esters in the Mukaiyama Aldol Reaction: A Powerful and Convenient Alternative to Aldehydes

作者:Inamoto Yoshihiro; Nishimoto Yoshihiro; Yasuda Makoto; Baba Akio*
来源:Organic Letters, 2012, 14(4): 1168-1171.
DOI:10.1021/ol3001443

摘要

An indium triiodide catalyst promoted the direct transformation from esters to beta-hydroxycarbonyl compounds using hydrosilanes and silyl enolates by a one-stage process. Various esters were applicable, and the high chemoselectivity of this system brings compatibility to many functional groups: alkenyl, alkynyl, chloro, and hydroxy.

  • 出版日期2012-2-17