A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates

作者：Maguire Nuala M; Ford Alan; Clarke Sarah L; Eccles Kevin S; Lawrence Simon E; Brossat Maude; Moody Thomas S; Maguire Anita R^*

来源：Tetrahedron: Asymmetry , 2011, 22(24): 2144-2150.

DOI：10.1016/j.tetasy.2011.11.022

The preparation of enantiopure cyanohydrin acetates via enzymatic hydrolysis has been investigated by screening a range of biocatalysts and reaction conditions. Enzymatic resolution has been optimised through variation of the hydrolase biocatalyst and reaction conditions leading to synthetically useful routes to enantiopure cyanohydrin acetates.

• 出版日期2011-12-31