An efficient, practical synthesis of 2-methoxyestradiol

作者：Xin, Minhang; You, Qidong; Xiang, Hua^*

来源：Steroids, 2010, 75(1): 53-56.

DOI：10.1016/j.steroids.2009.09.013

• 2-Methoxyestradiol
• Copper-mediated methoxylation
• Ethyl acetate
• Co-catalyst
• Synthesis

An efficient and practical scheme to synthesize 2-methoxyestradiol has been developed. The key step was the copper-mediated methoxylation using ethyl acetate as a co-catalyst to introduce a methoxyl group. These synthetic procedures of four steps from 17 beta-estradiol as starting material gave 2-methoxyestradiol with a 61% overall yield.

• 出版日期2010-1
• 单位中国药科大学