科研之友
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摘要
Background: Immunoglobulin G4 (IgG4)-related disease has been suggested to be involved in cardiovascular disorders such as chronic periaortitis. However, it remains unclear whether IgG4-related immuno-inflammation affects the subclinical stages of aortic remodeling. Here, we analyzed the relationship between serum IgG4 concentrations and the morphology of the ascending aorta. Methods: Serum concentrations of IgG4 were measured in 322 patients who underwent 320-slice cardiac computed tomography (CT). We assessed the aortic wall area and intravascular area at the portion between the. aortic valve and the bifurcation of the pulmonary artery. Results: In total, 174 patients (54.0%) were diagnosed to have coronary artery disease (CAD) by cardiac CT. The intravascular area was significantly larger in patients with CAD than in those without (893 mm(2) vs. 811 mm(2), p = 0.001). The aortic wall area was slightly, but not significantly, larger in patients with CAD than in those without (183 mm(2) vs. 176 mm(2), p = 0.051). Serum concentrations of IgG4 were significantly higher in patients with an aortic wall area of median or greater size (>= 181 mm(2)) than in those with a smaller area (<181 mm(2)) (32.9 mg/dL vs. 23.1 mg/dL, p = 0.026). In logistic regression analysis using age, gender, and CAD as covariates, the fourth quartile of IgG4 (>= 55.4 mg/dL) was significantly associated with an aortic wall area of median or greater size with an odds ratio of 2.09. Conclusions: Serum concentrations of IgG4 were found to be significantly associated with the aortic wall area. These findings collectively suggest that immuno-inflammatory processes may play a role in the subclinical stages of aortic remodeling.
- 出版日期2015-2
