The prognostic value of plasma fibrinogen levels in patients with endometrial cancer: a multi-centre trial

作者：Seebacher V^*; Polterauer S; Grimm C; Husslein H; Leipold H; Hefler Frischmuth K; Tempfer C; Reinthaller A; Hefler L

来源：British Journal of Cancer, 2010, 102(6): 952-956.

DOI：10.1038/sj.bjc.6605547

• fibrinogen
• endometrial cancer
• prognosis

BACKGROUND: To analyse the correlation between pre-treatment plasma fibrinogen levels and clinical-pathological parameters in patients with endometrial cancer and to assess the value of plasma fibrinogen as a prognostic parameter.
METHODS: Within a retrospective multi-centre study, the records of 436 patients with endometrial cancer were reviewed and pre-treatment plasma fibrinogen levels were correlated with clinical-pathological parameters and patients' survival.
RESULTS: The mean (s.d.) pre-treatment plasma fibrinogen level was 388.9 (102.4) mg per 100 ml. Higher plasma fibrinogen levels were associated with advanced tumour stage (FIGO I vs II vs III and IV, P = 0.002), unfavourable histological subtype (endometrioid vs non-endometrioid histology, P = 0.03), and higher patients' age (<= 67 years vs > 67 years, P = 0.04), but not with higher histological grade (G1 vs G2 vs G3, P = 0.2). In a multivariate analysis, tumour stage (P < 0.001 and P < 0.001), histological grade (P = 0.009 and P = 0.002), patients' age (P = 0.001 and P < 0.001), and pre-treatment plasma fibrinogen levels (P 0.04 and P = 0.02) were associated with disease-free and overall survival, respectively.
CONCLUSION: Plasma fibrinogen levels can be used as an independent prognostic parameter for the disease-free and overall survival of patients with endometrial cancer. British Journal of Cancer (2010) 102, 952-956. doi:10.1038/sj.bjc.6605547 www.bjcancer.

• 出版日期2010-3-16