Sixty-five novel alleles at the HLA-A, -B, and-DRB1 loci identified from National Marrow Donor Program volunteer donors

作者：Lazaro A M; Xiao Y; Regenscheid A; Ng J; Hurley C K; Posch P E^*

来源：Tissue Antigens, 2010, 76(4): 319-324.

DOI：10.1111/j.1399-0039.2010.01524.x

• DNA sequencing
• human leukocyte antigen-A
• -B
• -DRB1

Sixty-five novel human leukocyte antigen (HLA) alleles are described from volunteer donors of the 'Be The Match Registry (R)': 29 HLA-A alleles, 24 HLA-B alleles, and 12 HLA-DRB1 alleles. Eight (similar to 12%) of the novel alleles were found in more than one individual and may be more common in the population. Forty (similar to 62%) of the 65 novel alleles are single nucleotide substitution variants when compared with their most homologous allele. Two of these single nucleotide variants are silent substitutions and one creates a null allele. The remaining novel alleles differ from their most similar allele by 2-10 nucleotide substitutions. Some of the novel alleles encode amino acid changes at codons not previously reported to be polymorphic, such as codons 23, 93, 129, and 155 in HLA-A alleles and codon 3 in HLA-B alleles.

• 出版日期2010-10