A Facile Synthesis of C-2- Symmetric Macrocyclic Polyethers by Photodimerization of Covalently- linked Flavonoid Derivatives

作者：Uemura Naohiro; Ishikawa Hiroki; Yoshida Wataru; Katabira Satoshi; Yagishita Fumitoshi; Yoshida Yasushi; Mino Takashi; Kasashima Yoshio; Sakamoto Masami^*

来源：Chemistry Letters, 2018, 47(2): 160-162.

DOI：10.1246/cl.170955

• Cyclic polyether
• Photodimerization
• C-2-symmetric structure

C-2-Symmetric cyclic polyethers were conveniently provided by the photochemical dimerization of covalently-linked 2-chromonecarboxylic esters. Irradiation of polyethers possessing 2-chromonecarboxylate groups at both ends efficiently promoted intramolecular [2+2] cyclobutane formation leading to 14- to 23-membered cyclic polyethers in good chemical yields and quantum efficiencies. X-ray crystallographic analysis revealed that the stereochemistry of the cyclobutane was the C-2-symmetric structure.

• 出版日期2018