New drug for pancreatic cancer highlights the dual effect of regulatory approvals

作者:Bates Susan E*; Fojo Tito
来源:Nature Reviews Clinical Oncology, 2016, 13(4): 205-206.
DOI:10.1038/nrclinonc.2016.22

摘要

The recent FDA approval of MM-398 as a second-line treatment of metastatic pancreatic cancer, based on a 1.9-month overall survival benefit observed in the NAPOLI-1 trial, adds a new therapeutic option for this notoriously difficult-to-treat disease; however, by discouraging clinical trial enrolment, this approval might have negative consequences for the development of novel agents, which remain an essential unmet need.

  • 出版日期2016-4