A rapid and efficient domino protocol for the synthesis of functionalized benzo[a]pyrano[2,3-c]phenazine and benzo[f]pyrano[2,3-h]quinoxaline derivatives

作者：Mohebat Razieh^*; Abadi Afshin Yazdani Elah; Maghsoodlou Malek Taher

来源：Research on Chemical Intermediates, 2016, 42(6): 6039-6048.

DOI：10.1007/s11164-016-2437-7

• Multi-component domino reactions (MDRs)
• Tetracyanoethylene
• Pyridine
• Benzo[a] pyrano[2,3-c] phenazine
• Benzo[f]pyrano[2,3-h]quinoxaline

Benzo[a]pyrano[2,3-c]phenazine and benzo[f]pyrano[2,3-h]quinoxaline derivatives were synthesized via a one-pot, two-step procedure from a three-component condensation reaction of 2-hydroxynaphthalene-1,4-dione, 1,2-diamines, and tetracyanoethylene in the presence of pyridine as an efficient catalyst. This novel procedure has the advantages of operational simplicity, short reaction times, easy work-up, avoiding costly syntheses, and the products do not require further purification, which provides an efficient and economical method for the synthesis of related products in excellent yields.

• 出版日期2016-6