A new fully covered metal stent with anti-migration features for the treatment of malignant dysphagia

作者：Walter Daisy^*; van den Berg Maarten W; van Hooft Jeanin E; Boot Henk; Scheffer Robert C H; Vleggaar Frank P; Siersema Peter D

来源：Endoscopy, 2014, 46(12): 1101-1105.

DOI：10.1055/s-0034-1377632

Background and study aims: A new esophageal stent with two anti-migration features was developed to minimize migration. The aim of this study was to evaluate the clinical efficacy and safety of this stent in patients with malignant dysphagia. %26lt;br%26gt;Patients and methods: A total of 40 patients with dysphagia due to a malignant obstruction of the esophagus were prospectively enrolled in this cohort study. %26lt;br%26gt;Results: Stent placement was technically successful in 39 patients (98%). The median dysphagia-free time after stent placement was 220 days (95% confidence interval 94-345 days). Nine patients (23%) experienced recurrent dysphagia due to tissue overgrowth (n=2), stent fracture (n=1), and partial (n=5) or complete (n=1) stent migration. A total of 16 serious adverse events occurred in 14 patients (36%), with hemorrhage (n=3) and severe nausea or vomiting (n=3) being the most common causes. %26lt;br%26gt;Conclusions: This new stent design was effective for the palliation of malignant dysphagia and had a low rate of recurrent dysphagia. However, despite the anti-migration features, stent migration was still a major cause of recurrent dysphagia. Furthermore, treatment was associated with a high adverse event rate.

• 出版日期2014-12