Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

作者：Li Li Jie^*; Li Ming Yi; Li Yan Tuan; Feng Jing Jing; Hao Feng Qiang; Zhang Lun

来源：Marine Drugs, 2012, 10(12): 2648-2660.

DOI：10.3390/md10122648

• Sargassum pallidum polysaccharide
• combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines
• antibody titer
• T lymphocytes

This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.

• 出版日期2012-12
• 单位中国海洋大学