科研之友
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摘要
Background: In healthy individuals, intraduodenal whey protein load-dependently modulates gastrointestinal motor and hormonal functions and suppresses energy intake. The effect of oral whey, particularly the impact of load, has not been evaluated. Objective: The purpose of this study was to quantify gastric emptying of 30 and 70 g of oral whey protein loads and their relation to gastrointestinal hormone, glycemic, and appetitive responses. Design: On 3 separate occasions in a randomized, double-blind order, 18 lean men [mean +/- SEM age: 24.8 +/- 1.4 y; body mass index (in kg/m(2)): 21.6 +/- 0.5] received iso-osmolar, equally palatable drinks (similar to 450 mL) containing 30 g pure whey protein isolate (L), 70 g pure whey protein isolate (H), or saline (control). Gastric emptying (with the use of 3-dimensional ultrasound), plasma cholecystokinin, glucagon-like peptide 1, glucose-dependent insulinotropic peptide, insulin, glucagon, total amino acids, and blood glucose were measured for 180 min after consumption of the drinks, and energy intake at a buffet-style lunch was quantified. Results: Gastric emptying of the L and H drinks was comparable when expressed in kilocalories per minute (L: 2.6 +/- 0.2 kcal/min; H: 2.9 +/- 0.3 kcal/min) and related between individuals (r = 0.54, P < 0.01). Gastrointestinal hormone, insulin, and glucagon responses to the L and H drinks were comparable until similar to 45-60 min after ingestion, after which time the responses became more differentiated. Blood glucose was modestly reduced after the H drink between t = 45 and 150 min when compared with the L drink (all P < 0.05). Energy intake was suppressed by both L and H drinks compared with control (P < 0.05) (control: 1174 +/- 91 kcal; L: 1027 +/- 81 kcal; and H: 997 +/- 71 kcal). Conclusion: These findings indicate that, in healthy lean men, the rate of gastric emptying of whey protein is independent of load and determines the initial gastrointestinal hormone response.
- 出版日期2015-12
- 单位河北医科大学
