Nanoparticle-Assisted Stimulated-Emission-Depletion Nanoscopy

作者：Sivan Yonatan^*; Sonnefraud Yannick; Kena Cohen Stephane; Pendry John B; Maier Stefan A

来源：ACS Nano, 2012, 6(6): 5291-5296.

DOI：10.1021/nn301082g

• plasmonics
• STED microscopy
• super-resolution
• nanoshells
• photobleaching
• triplets

We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Our scheme may allow improvement of existing STED nanoscopes and assist in the development of low-power, low-cost nanoscopes. This has the potential to increase the availability of STED nanoscopes and lead to a significant expansion of our understanding of biological and biochemical phenomena occurring on the nanoscale.

• 出版日期2012-6