Decision modelling of economic evaluation of intervention programme of breast cancer

作者：Chang Jung Chen; Chen Tony H H^*; Duffy Stephen W; Yen Amy M F; Chen Sam L S

来源：Journal of Evaluation in Clinical Practice, 2010, 16(6): 1282-1288.

DOI：10.1111/j.1365-2753.2009.01329.x

• breast cancer
• cost-benefit analysis
• cost-effectiveness analysis
• cost-utility analysis
• decision model
• Markov model
• probabilistic approach

Objectives
Economic appraisal of an intervention is a complex and multivariable problem, with probabilistic issues related not only to clinical outcomes but also to costs and willingness to pay.
Methods
We provide a comprehensive framework for economic appraisal of a health intervention to prevent beast cancer mortality, involving probabilistic model of costs as well as of aspects of the disease process. The economic appraisal can give a range of probabilities of cost-effectiveness depending on willingness or ability to pay.
Results
We apply the method to the example of polychemotherapy for early breast cancer. Results indicate a 30% probability of cost-effectiveness for a willingness to pay of $60 000 per quality-adjusted life-year and around 50% for a threshold of $100 000.
Conclusion
The comprehensive economic appraisal model is a powerful tool for decision making over a range of economic environments.

• 出版日期2010-12