MR angiography of carotid artery aneurysms in a porcine model at 3 tesla: Comparison of two different macrocyclic gadolinium chelates and of dynamic and conventional techniques

作者：Wuesten Oliver^*; Morelli John N; Miller Matthew W; Tuzun Egemen; Lenox Mark W; Fossum Theresa W; Trelles Miguel; Cotes Claudia; Krombach Gabriele A; Runge Val M

来源：Journal of Magnetic Resonance Imaging, 2012, 36(5): 1203-1212.

DOI：10.1002/jmri.23757

• magnetic resonance angiography
• gadolinium-based contrast agents
• carotid aneurysms
• nephrogenic systemic fibrosis

Purpose: To evaluate the differences in image quality of two macrocyclic gadolinium-based contrast agents, gadobutrol and gadoterate meglumine, using time-resolved, contrast-enhanced MR angiography (CE-MRA) in a porcine carotid artery aneurysm model and to compare image quality between dynamic and conventional, single acquisition CE-MRA. Materials and Methods: Bilateral carotid aneurysms were created surgically in this Institutional Animal Care and Use Committee approved study. Dynamic CE-MRA studies optimized for high temporal resolution were performed at 3 Tesla. Scans using equivalently dosed (on a per mmol basis) gadobutrol and gadoterate meglumine were compared qualitatively and quantitatively in terms of contrast-to-noise ratio (CNR). Higher spatial resolution dynamic and conventional CE-MRA were also compared. Results: N = 16 aneurysms were assessed. Qualitative evaluation of dynamic CE-MRA scans demonstrated a preference for gadobutrol over gadoterate meglumine. Significantly higher aneurysm CNR was found with gadobutrol (133 +/- 44) versus gadoterate meglumine, the latter at both equivalent and double injection rates (94 +/- 35 and 102 +/- 38). In a blinded assessment, conventional CE-MRA was preferred qualitatively when compared with dynamic CE-MRA. However, dynamic CE-MRA was generally capable of providing diagnostic image quality. Conclusion: Gadobutrol is preferred to gadoterate meglumine for high temporal resolution dynamic CE-MRA, a fact with important clinical implications for low dose CE-MRA protocols in patients at risk for nephrogenic systemic fibrosis. Conventional high resolution CE-MRA provides superior image quality when compared with dynamic CE-MRA. J. Magn. Reson. Imaging 2012;36:12031212.

• 出版日期2012-11