Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors - Case reports and a review of literature

作者：Zhang Grace; Basti Surendra^*; Jampol Lee M

来源：Cornea, 2007, 26(7): 858-860.

DOI：10.1097/ICO.0b013e318064584a

• trichomegaly
• external ocular changes
• epidermal growth factor receptor inhibitors
• acneiform skin changes
• blepharitis
• meibomitis

Purpose: To report the external ocular changes in 2 patients receiving epidermal growth factor receptor (EGFR) inhibitors.
Methods: Retrospective observational case series. Two patients receiving epidermal growth factor inhibitors for metastatic nonsmall-cell lung carcinoma were followed clinically and with external photographs.
Results: Findings included acneiform facial changes, telangiectasia of eyelid margins, meibomitis, tear film dysfunction, and unusual, hyperpigmented, tortuous eyelashes.
Conclusions: EGFR inhibitors used in the treatment of certain malignancies can lead to symptomatic adnexal and ocular surface changes. Ophthalmologists should be aware of these to appropriately manage them.

• 出版日期2007-8
• 单位西北大学