Hereditary Colorectal Cancer: Genetics and Screening

作者：Brosens Lodewijk A A^*; Offerhaus G Johan A; Giardiello Francis M

来源：Surgical Clinics of North America, 2015, 95(5): 1067-+.

DOI：10.1016/j.suc.2015.05.004

• Colorectal cancer
• Hereditary nonpolyposis colorectal cancer
• Lynch syndrome
• Familial adenomatous polyposis
• MUTYH-associated polyposis

Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.

• 出版日期2015-10