Association between the prothrombin G20210A mutation and sudden sensorineural hearing loss in European population: A meta-analysis

作者：Shu, Jingcheng; Yin, Shihua^*; Tan, An-Zhou; He, Meirong

来源：Thrombosis Research, 2015, 135(1): 73-77.

DOI：10.1016/j.thromres.2014.10.032

• Prothrombin
• Mutation
• Sudden sensorineural hearing loss
• Meta-analysis

Purpose: Epidemiological studies have reported inconsistent findings on the association between the prothrombin G20210A mutation and sudden sensorineural hearing loss (SSNHL) in European population. The aim of this meta-analysis was to clarify the association of this polymorphism with SSNHL in European population.
Methods: PubMed, Embase, and the China National Knowledge Infrastructure (CNKI) were searched up to August 1, 2014. We used STATA12.0 to calculate summary odds ratios (ORs) with 95% confidence intervals (CIs).
Results: Eight studies including 1972 patients were identified. Pooled data showed no significant association between the prothrombin G20210A mutation and risk of SSNHL in European population : A vs. G (OR = 1.645, 95% CI:0.78-3.49, POR = 0.194); AG vs. GG (OR = 1.660, 95% CI:0.77-3.60, POR = 0.199).
Conclusions: The present meta-analysis suggests that the prothrombin G20210A mutation is not significantly associated with an increased risk of SSNHL in European population.

• 出版日期2015-1
• 单位广西医科大学