Development of cetyl dimethicone based water-in-oil emulsion containing botanicals: Physical characteristics and stability

作者：Waqas Muhammad Khurram^*; Akhtar Naveed; Shah Pervaiz Akhtar; Danish Muhammad Zeeshan; Shah Arshad Ali; Braga Valdir de Andrade; Khan Barkat Ali^*

来源：Pakistan Journal of Pharmaceutical Sciences, 2016, 29(1): 173-178.

• Grape seed extract
• w/o Emulsion
• stability
• pH
• electrical conductivity
• and rheology

The aim of current research was to develop a water-in-oil emulsion containing grape seed extract for application in cosmeceuticals. Finally grinded dried grape seeds powder was extracted with hydro alcoholic mixture. Emulsions consisting of different concentrations of cetyl dimethicone (Abile EM90), the nonionic emulsifier, liquid paraffin as oily phase and water as aqueous phase were developed. Color, odor, pH, viscosity, liquefaction, phase separation, centrifugation and thermal stability of the formulated emulsions were observed at various storage temperatures i.e. 8 +/- 0.5 degrees C, 25 +/- 0.5 degrees C, 40 +/- 0.5 degrees C and 40 degrees C +/- 0.5 degrees C with 70% RH. The stable formulation consist of 16% mineral oil, 4% of ABIL EM 90 (R), 4% grape seeds extract, 1% rose oil and 75% distilled water. All the results derived from this study showed good stability over the three months study period which indicates w/o emulsion can be used as carrier of 4% grape seeds extract to enhance desired effects when applied topically.

• 出版日期2016-1