A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

作者:Hamieh Saleh; Ludlow R Frederick; Perraud Olivier; West Kevin R; Mattia Elio; Otto Sijbren*
来源:Organic Letters, 2012, 14(21): 5404-5407.
DOI:10.1021/ol302260n

摘要

Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.

  • 出版日期2012-11-2