Anti-Lymphangiogenesis Effects of a Specific Anti-Interleukin 7 Receptor Antibody in Lung Cancer Model In Vivo

作者：Ming Jian; Zhang Qingfu; Jiang Yanduo; Jiang Guocheng; Qiu Xueshan^*

来源：Molecular Carcinogenesis, 2015, 54(2): 148-155.

DOI：10.1002/mc.22082

• interleukin 7
• interleukin 7 receptor
• lung cancer
• in vivo
• lymphangiogenesis

Interleukin 7 (IL-7) is known to promote lymphangiogenesis. To study the relationship between IL-7 and the lymphangiogenesis in lung cancer cells xenograft tumors, we investigated how IL-7 regulates lymphangiogenesis by Quantitative real-time reverse transcriptase-polymerase chain reaction, Western blot, co-immunoprecipitation, chromatin immunoprecipitation, and immunohistochemistry methods. We found that, in lung cancer cells xenograft tumors IL-7/IL-7 receptor (IL-7R) increase the expression of VEGF-D and lymphangiogenesis, induce c-Fos and c-Jun heterodimer formation, and enhance c-Fos/c-Jun DNA binding activity to regulate VEGF-D. Taken together, our results provided evidence that IL-7/IL-7R induce VEGF-D upregulation and promote lymphangiogenesis via c-Fos/c-Jun pathway in lung cancer.

• 出版日期2015-2
• 单位中国人民解放军第二O二医院; 中国医科大学