A Phenylpropanoid, a Slovenolide, Two Sulphur-Containing Germacranes and Ca2 -ATPase Inhibitors from Thapsia villosa

作者：Rubal Juan J; Javier Moreno Dorado F; Guerra Francisco M; Jorge Zacarias D; del Carmen Galan Maria; Salido Gines M; Christensen Soren B; Sohoel Helmer; Massanet Guillermo M^*

来源：Planta Medica, 2010, 76(3): 284-290.

DOI：10.1055/s-0029-1186056

• Thapsia villosa
• Apiaceae
• germacranes
• phenylpropanoids
• slovenolides
• thapsigargins
• transtaganolides
• Ca2 -ATPase inhibitors

A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca2 -dependent ATPases (SERCA) pump.

• 出版日期2010-2